ENTvantage Diagnostics, of Austin, Texas, is developing a device to improve the accuracy of diagnosis of sinusitis (sinus infections). Although bacteria cause sinusitis only about 10 percent of the time, physicians commonly prescribe antibiotics, which are ineffective against non-bacterial sinusitis. Because diagnostic tools are not currently available for a proper diagnosis, clinicians have to rely on imprecise diagnostic algorithms based solely on the patient symptoms. ENTvantage aims to create a point-of-care assay device to provide rapid results that are simple to interpret with ease of use and minimal staff training. In a manner similar to that of rapid influenza A and B tests commonly used in primary care clinics, this new device is envisioned to reduce unnecessary antibiotic usage.